The 1998–99 Detroit Titans men's basketball team represented the University of Detroit Mercy in the 1998–99 NCAA Division I men's basketball season. Led by coach Perry Watson, the Titans played their home games at Cobo Arena as members of the Midwestern Collegiate Conference. They finished the season 25–6 overall, 12–2 in Horizon League play to win the regular season league title. This 1998–99 team, which tied the school record with 25 wins, reached the NCAA Tournament in back-to-back seasons for the first, and only, time in school history.