The 2005–06 Georgetown Hoyas men's basketball team was an NCAA Division I college basketball team competing in the Big East Conference, representing Georgetown University. The team raced out to an 11–4 record including an 8–2 mark in out of conference play. John Thompson III's first notable win with the team took place on January 21, 2006 in the 16th game of the season when unranked Georgetown upset No. 1 Duke University. This was Georgetown's first win over a No. 1 ranked team in 21 years. The team received an at-large bid to the NCAA tournament and advanced to the Minneapolis Region Semifinal in the "Sweet Sixteen", where it came the closest of any team to beating the eventual national champion, Florida.