The 2006 USL Premier Development League season was the 12th PDL season. The season began in April 2006 and ended in August 2006. Michigan Bucks finished the season as national champions, beating Laredo Heat 2–1 in the PDL Championship game in Laredo, Texas on 12 August 2006. Carolina Dynamo finished with the best regular season record in the league, winning 14 out of their 16 games, suffering no losses, and finishing with a +29 goal difference. Cape Cod Crusaders finished a very close second, tied with Dynamo on points and goal difference, but having scored two less goals.