The 2010 Autism Speaks 400 presented by Hershey's Milk & Milkshakes was the twelfth race of the 2010 NASCAR Sprint Cup Series season held at Dover International Speedway in Dover, Delaware. The race started at 1 p.m. EST on May 16, 2010 and was broadcast on Fox and MRN radio starting at 12 p.m. Martin Truex Jr. started in the pole position. The race had eight different leaders, twenty lead changes, and five cautions. The winner of the race was Kyle Busch, while Jeff Burton and Matt Kenseth finished second and third respectively.