The 2010 Southeast Missouri State Redhawks football team represented Southeast Missouri State University as a member of the Ohio Valley Conference (OVC) during the 2010 NCAA Division I FCS football season. Led by fifth-year head coach Tony Samuel, the Redhawks compiled an overall record of 9–3 with a mark of 7–1 in conference play, winning the OVC title. Southeast Missouri State received an automatic bid to the NCAA Division I Football Championship playoffs, where the Redhawks lost in second round to the eventual national champion, Eastern Washington. The team played home games at Houck Stadium in Cape Girardeau, Missouri.