2016 Regional League Division 2 Central Region is the 1st season of the League competition since its establishment in 2016. It is in the third tier of the Thai football league system. The league winners and runners up will qualify for the 2016 Regional League Division 2 champions league round. This zone is broken from 2015 Thai Division 2 League Central & Eastern Region and 2015 Thai Division 2 League Central & Western Region