The 2017–18 Penn Quakers women's basketball team represents the University of Pennsylvania during the 2017–18 NCAA Division I women's basketball season. The Quakers, led by ninth year head coach , play their home games at the Palestra and were members of the Ivy League. They finished the season 22–9, 11–3 to finish in second place. They advanced to the championship game of the Ivy League women's tournament where they lost to Princeton. They received an automatic trip to the Women's National Invitation Tournament where they defeated Albany in the first before losing to St. John's in the second round.