The 2018–19 Houston Cougars women's basketball team represented the University of Houston during the 2018–19 NCAA Division I women's basketball season. The season marked the sixth for the Cougars as members of the American Athletic Conference. The Cougars were led by fifth-year head coach . They played their home games at Fertitta Center, which reopened on December 1, 2018, after a $60 million upgrade. The Cougars played their first three non-conference home games at H&PE Arena while construction on Fertitta Center was completed. They finished the season 15–16, 9–7 in The American play to finish in fourth place. They lost to South Florida in the quarterfinals of the American Athletic Conference women's tournament. They received an at-large bid to the Women's National Invitation Tournament,