The 2018 Holy Cross Crusaders football team represented the College of the Holy Cross as a member of the Patriot League during the 2018 NCAA Division I FCS football season. Led by first-year head coach Bob Chesney, Holy Cross compiled an overall record of 5–6 with a mark of 4–2 in conference play, tying for second place in the Patriot League. The Crusaders played their home games at Fitton Field in Worcester, Massachusetts.