The 2018 South Dakota State Jackrabbits football team represented South Dakota State University in the 2018 NCAA Division I FCS football season. They were led by 22nd-year head coach John Stiegelmeier and played their home games at Dana J. Dykhouse Stadium in Brookings, South Dakota as members of the Missouri Valley Football Conference. They finished the season 10–3, 6–2 in MVFC play to finish in second place. They received an at-large bid to the FCS Playoffs where they defeated Duquesne in the second round and Kennesaw State in the quarterfinals, before losing in the semifinals to North Dakota State.