The 2020–21 season was Milton Keynes Dons' 17th season in their existence, and the club's second consecutive season in League One. The club also competed in the FA Cup, EFL Cup and EFL Trophy. Due to the impact of the COVID-19 pandemic, league fixtures commenced on 12 September 2020, approximately a month later than previous seasons. The season covers the period from 1 July 2020 to 30 June 2021.