The 2021–22 Drake Bulldogs men's basketball team represented Drake University during the 2021–22 NCAA Division I men's basketball season. The Bulldogs were led by fourth-year head coach Darian DeVries. They played their home games at the Knapp Center in Des Moines, Iowa as members of the Missouri Valley Conference (MVC). They finished the regular season 22–9, 13–5 in MVC play to finish in a tie for second place. As the No. 3 seed in the MVC tournament, they defeated Southern Illinois in the quarterfinals and Missouri State in the semifinals before losing to Loyola in the championship.