The 2021–22 season was FC Midtjylland's 23rd season of existence, and their 21st consecutive season in the Danish Superliga, the top tier of football in Denmark. As a result of the club's runner-up finish in 2020–21, it competed in the 2021–22 UEFA Champions League, and subsequently in the 2021–22 UEFA Europa League and the 2021-22 UEFA Europa Conference League. The Black Wolves completed a successful 2021–22 campaign with a second-place finish in the Superliga, again qualifying for the Champions League, and also captured its second Danish Cup, after defeating OB in the final on penalties.