The 2021–22 Women's Senior T20 Trophy was the 13th edition of the Women's Senior T20 Trophy, the domestic women's T20 competition in India. The tournament was originally scheduled to be played from 19 March to 11 April 2022, but was postponed on 5 January 2022 due to rising COVID-19 cases in the country. The tournament took place from 15 April to 4 May 2022, with 37 teams divided into six groups. In the first round of the tournament, Nagaland player Kiran Navgire scored an unbeaten 162 against Arunachal Pradesh. Railways, the defending champions, beat Maharashtra in the final to win their tenth T20 title.