The 2021–22 Youngstown State Penguins men's basketball team represents Youngstown State University in the 2021–22 NCAA Division I men's basketball season. The Penguins, led by fifth-year head coach Jerrod Calhoun, played their home games at the Beeghly Center in Youngstown, Ohio as members of the Horizon League. they finished the regular season 18–14, 12–9 in Horizon League play to finish in seventh place. They lost to Robert Morris in the first round of the Horizon League tournament. The Penguins accepted an invitation to play in The Basketball Classic tournament, formerly known as the CollegeInsider.com Tournament.