The 2021 Birmingham Bowl was a college football bowl game played on December 28, 2021, with kickoff at 12:00 p.m. EST (11:00 a.m. local CST) and televised on ESPN. It was the 15th edition of the Birmingham Bowl (after the 2020 edition was cancelled due to the COVID-19 pandemic), and was one of the 2021–22 bowl games concluding the 2021 FBS football season. Sponsored by the TicketSmarter ticket sales company, the game was officially known as the TicketSmarter Birmingham Bowl. This was the first edition of the bowl played at Protective Stadium.