The 2021 Valdosta State Blazers football team represented Valdosta State University as a member of the Gulf South Conference (GSC) during the 2021 NCAA Division II football season. They were led by third-year head coach Gary Goff. The Blazers played their home games at Bazemore–Hyder Stadium in Valdosta, Georgia. The Blazers competed for the 2021 NCAA Division II Football Championship Game against Ferris State. This was their first appearance in the championship game since the 2018 game.