The 2022 Argentine Republic motorcycle Grand Prix (officially known as the Gran Premio Michelin de la República Argentina) was the third round of the 2022 Grand Prix motorcycle racing season. It was held at the Autódromo Termas de Río Hondo in Termas de Río Hondo on 3 April 2022. In the MotoGP race, Aleix Espargaró won the race on his 200th MotoGP appearance after starting from pole position to take his and Aprilia's both maiden pole and victory in the premier class.