The 2022 Cook Out Southern 500, the 59th running of the event, was a NASCAR Cup Series race that was held on September 4, 2022, at Darlington Raceway in Darlington, South Carolina. Contested over 367 laps on the 1.366-mile (2.198 km) egg-shaped oval, it was the 27th race of the 2022 NASCAR Cup Series season, the first race of the 2022 NASCAR playoff, and the first race of the Round of 16.