The 2022 NCAA Division I Women's Lacrosse Championship was the 40th annual single-elimination tournament to determine the national champion of Division I NCAA women's college lacrosse. The semifinal and championship rounds will be played at Homewood Field in Baltimore, MD from May 27–29, 2022. All other rounds will be played at campus sites, usually at the home field of the higher-seeded team, from May 13–19.