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5′-Nucleotidase (EC 3.1.3.5) is an enzyme which catalyzes the phosphorylytic cleavage of 5′-nucleotides. Although originally found in snake venom, the activity of 5'nucleotidase has been described for bacteria and plant cells, and is widely distributed in vertebrate tissue. In mammalian cells the enzyme is predominantly located in the plasma membrane and its primary role is in the conversion of extracellular nucleotides (e.g. 5'-AMP), which are generally impermeable, to the corresponding nucleoside (e.g. adenosine) which can readily enter most cells. Consequently, the enzyme plays a key role in the metabolism of nucleotides.

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  • 5'-nucleotidase (en)
  • 5'-Nucleotidasa (es)
  • 5'-ヌクレオチダーゼ (ja)
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  • La 5'-nucleotidasa (EC 3.1.3.5), es una enzima que cataliza la siguiente reacción química: un 5'-ribonucleótido + H2O un ribonucleósido + fosfato Por lo tanto los dos sustratos de esta enzima son un 5'-ribonucleótido y agua, mientras que sus dos productos son un ribonucleósido y fosfato. (es)
  • 5'-ヌクレオチダーゼ(5'-nucleotidase、EC 3.1.3.5)は、5'-リボヌクレオチド ホスホヒドロラーゼという系統名を持つ酵素である。以下の化学反応を触媒する。 5'-リボヌクレオチド + 水リボヌクレオシド + リン酸 従って、この酵素の2つの基質は5'-リボヌクレオチドと水、2つの生成物はリボヌクレオシドとリン酸である。 この酵素は、5'-ヌクレオチドに対して広い特異性を持つ。 (ja)
  • 5′-Nucleotidase (EC 3.1.3.5) is an enzyme which catalyzes the phosphorylytic cleavage of 5′-nucleotides. Although originally found in snake venom, the activity of 5'nucleotidase has been described for bacteria and plant cells, and is widely distributed in vertebrate tissue. In mammalian cells the enzyme is predominantly located in the plasma membrane and its primary role is in the conversion of extracellular nucleotides (e.g. 5'-AMP), which are generally impermeable, to the corresponding nucleoside (e.g. adenosine) which can readily enter most cells. Consequently, the enzyme plays a key role in the metabolism of nucleotides. (en)
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  • 5′-nucleotidase (en)
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  • http://commons.wikimedia.org/wiki/Special:FilePath/5'nucleotidase_membrane-bound_and_soluble_form_schematic.png
  • http://commons.wikimedia.org/wiki/Special:FilePath/5NT_Active_Site.png
  • http://commons.wikimedia.org/wiki/Special:FilePath/5NT_PDB_Image.png
  • http://commons.wikimedia.org/wiki/Special:FilePath/AMP_to_Adenosine_5'nucleotidase_catalyzed_reaction.png
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  • Human ecto-5'-nucleotidase : crystal form I in complex with adenosine (en)
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  • 5′-Nucleotidase (EC 3.1.3.5) is an enzyme which catalyzes the phosphorylytic cleavage of 5′-nucleotides. Although originally found in snake venom, the activity of 5'nucleotidase has been described for bacteria and plant cells, and is widely distributed in vertebrate tissue. In mammalian cells the enzyme is predominantly located in the plasma membrane and its primary role is in the conversion of extracellular nucleotides (e.g. 5'-AMP), which are generally impermeable, to the corresponding nucleoside (e.g. adenosine) which can readily enter most cells. Consequently, the enzyme plays a key role in the metabolism of nucleotides. The enzyme has a wide substrate specificity for nucleotides and has been shown to hydrolyze 5'nucleotides rapidly, ribose-5-phosphate slowly, and other phosphate esters extremely slowly (if at all). The enzyme catalyses the following reaction: a 5′-nucleotide + H2O ⇌ a nucleoside + phosphate The 5′-nucleotidase-catalyzed reaction of an AMP nucleotide to adenosine nucleoside is shown below: (en)
  • La 5'-nucleotidasa (EC 3.1.3.5), es una enzima que cataliza la siguiente reacción química: un 5'-ribonucleótido + H2O un ribonucleósido + fosfato Por lo tanto los dos sustratos de esta enzima son un 5'-ribonucleótido y agua, mientras que sus dos productos son un ribonucleósido y fosfato. (es)
  • 5'-ヌクレオチダーゼ(5'-nucleotidase、EC 3.1.3.5)は、5'-リボヌクレオチド ホスホヒドロラーゼという系統名を持つ酵素である。以下の化学反応を触媒する。 5'-リボヌクレオチド + 水リボヌクレオシド + リン酸 従って、この酵素の2つの基質は5'-リボヌクレオチドと水、2つの生成物はリボヌクレオシドとリン酸である。 この酵素は、5'-ヌクレオチドに対して広い特異性を持つ。 (ja)
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  • 3.1.3.5
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