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5-HTTLPR (serotonin-transporter-linked promoter region) is a polymorphic region in SLC6A4, the gene that codes for the serotonin transporter.Since the polymorphism was identified in the middle of the 1990s,it has been extensively investigated, e.g., in connection with neuropsychiatric disorders.A 2006 scientific article stated that "over 300 behavioral, psychiatric, pharmacogenetic and other medical genetics papers" had analyzed the polymorphism. While often discussed as an example of gene-environment interaction, this contention is contested.

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  • 5-HTTLPR (en)
  • 5-HTTLPR (pl)
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  • 5-HTTLPR (serotonin-transporter-linked promoter region) is a polymorphic region in SLC6A4, the gene that codes for the serotonin transporter.Since the polymorphism was identified in the middle of the 1990s,it has been extensively investigated, e.g., in connection with neuropsychiatric disorders.A 2006 scientific article stated that "over 300 behavioral, psychiatric, pharmacogenetic and other medical genetics papers" had analyzed the polymorphism. While often discussed as an example of gene-environment interaction, this contention is contested. (en)
  • 5-HTTLPR (ang. serotonin-transporter-linked polymorphic region) – obszar polimorficzny zlokalizowany w obrębie promotora genu SLC6A4 kodującego transporter serotoniny. Polimorfizm tego obszaru wiąże się z predyspozycją do reakcji depresyjnych na "stresujące" wydarzenia życiowe. Osoby z genotypem s/s i l/s ("s" - ang. short, krótki; "l" ang. long, długi) charakteryzują się większą częstością wystąpienia depresji po takich zdarzeniach niż osoby z genotypem l/l. Późniejsze badania doprowadziły także do odkrycia powiązań między 5-HTTLPR a występowaniem lękowych cech osobowości. (pl)
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  • http://commons.wikimedia.org/wiki/Special:FilePath/Chromosome_17.svg
  • http://commons.wikimedia.org/wiki/Special:FilePath/K.P._Lesch,_2014.jpg
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