Abdul Karim Khan was the ruler of Yarkand Khanate in what is now north-west China (Xinjiang) between 1560 and 1591. He was second son of Abdurashid Khan. During his reign, he lost control over a number of oases and merely acted as the titular figurehead ruler. Abdul Karim Khan was a descendant of the first Moghul Khan Tughlugh Timur (1347-1363). He came to power in 1560. He became the Khan as the eldest son in the family after the death of his father Abdurashid Khan. Abdul Karim Khan died in 1591 and was succeeded by his brother Muhammad Sultan.