About: Ankyrin-G binding motif of KCNQ2-3

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In molecular biology, the ankyrin-G binding motif of KCNQ2-3 is a protein motif found in the potassium channels KCNQ2 and KCNQ3. Interactions with ankyrin-G (ankyrin-3) are crucial to the localisation of voltage-gated sodium channels (VGSCs) at the axonal initial segment and for neurons to initiate action potentials. This conserved 9-amino acid motif ((V/A)P(I/L)AXXE(S/D)D) is required for ankyrin-G binding and functions to localise sodium channels to a variety of 'excitable' membrane domains both inside and outside of the nervous system. This motif has also been identified in the potassium channel 6TM proteins KCNQ2 and KCNQ3 that correspond to the M channels that exert a crucial influence over neuronal excitability. KCNQ2/KCNQ3 channels are preferentially localised to the surface of axo

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rdf:type	Thing Biomolecule Biomolecule Protein yago:Abstraction100002137 yago:Family108078020 yago:Group100031264 yago:Organization108008335 yago:YagoLegalActor yago:YagoLegalActorGeo yago:YagoPermanentlyLocatedEntity protein yago:SocialGroup107950920 yago:Unit108189659
rdfs:label	Ankyrin-G binding motif of KCNQ2-3 (en)
rdfs:comment	In molecular biology, the ankyrin-G binding motif of KCNQ2-3 is a protein motif found in the potassium channels KCNQ2 and KCNQ3. Interactions with ankyrin-G (ankyrin-3) are crucial to the localisation of voltage-gated sodium channels (VGSCs) at the axonal initial segment and for neurons to initiate action potentials. This conserved 9-amino acid motif ((V/A)P(I/L)AXXE(S/D)D) is required for ankyrin-G binding and functions to localise sodium channels to a variety of 'excitable' membrane domains both inside and outside of the nervous system. This motif has also been identified in the potassium channel 6TM proteins KCNQ2 and KCNQ3 that correspond to the M channels that exert a crucial influence over neuronal excitability. KCNQ2/KCNQ3 channels are preferentially localised to the surface of axo (en)
name	Ankyrin-G binding motif of KCNQ2-3 (en)
dcterms:subject	Molecular biology
Wikipage page ID	34491593 (xsd:integer)
Wikipage revision ID	1057948149 (xsd:integer)
Link from a Wikipage to another Wikipage	Proline Nervous system Valine KvLQT2 KvLQT3 Potassium channel Chordates dbr:Glutamic_acid Conserved sequence Leucine Action potential ANK3 Alanine Amino acid Molecular biology Evolution Cell membrane Protein Isoleucine Aspartic acid Phylogenetic Sodium channels Neurons Serine Voltage-gated channel Neuronal Potassium channels Vertebrates Protein motif Transmembrane Distally dbr:Axonal__initial_segment
sameAs	Ankyrin-G binding motif of KCNQ2-3 Ankyrin-G binding motif of KCNQ2-3 Ankyrin-G binding motif of KCNQ2-3
dbp:wikiPageUsesTemplate	dbt:Infobox_protein_family dbt:InterPro_content dbt:Reflist
InterPro	IPR020969 (en)
Pfam	PF11956 (en)
symbol	KCNQC3-Ank-G_bd (en)
has abstract	In molecular biology, the ankyrin-G binding motif of KCNQ2-3 is a protein motif found in the potassium channels KCNQ2 and KCNQ3. Interactions with ankyrin-G (ankyrin-3) are crucial to the localisation of voltage-gated sodium channels (VGSCs) at the axonal initial segment and for neurons to initiate action potentials. This conserved 9-amino acid motif ((V/A)P(I/L)AXXE(S/D)D) is required for ankyrin-G binding and functions to localise sodium channels to a variety of 'excitable' membrane domains both inside and outside of the nervous system. This motif has also been identified in the potassium channel 6TM proteins KCNQ2 and KCNQ3 that correspond to the M channels that exert a crucial influence over neuronal excitability. KCNQ2/KCNQ3 channels are preferentially localised to the surface of axons both at the axonal initial segment and more distally, and this axonal initial segment targeting of surface KCNQ channels is mediated by these ankyrin-G binding motifs of KCNQ2 and KCNQ3. KCNQ3 is a major determinant of M channel localisation to the AIS, rather than KCNQ2. Phylogenetic analysis reveals that anchor motifs evolved sequentially in chordates (NaV channel) and jawed vertebrates (KCNQ2/3). (en)
prov:wasDerivedFrom	wikipedia-en:Ankyrin-G_binding_motif_of_KCNQ2-3?oldid=1057948149&ns=0
page length (characters) of wiki page	4014 (xsd:nonNegativeInteger)
Symbol	KCNQC3-Ank-G_bd
foaf:isPrimaryTopicOf	wikipedia-en:Ankyrin-G_binding_motif_of_KCNQ2-3
is Link from a Wikipage to another Wikipage of	Axon
is foaf:primaryTopic of	wikipedia-en:Ankyrin-G_binding_motif_of_KCNQ2-3

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