About: BW-723C86

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BW-723C86 is a tryptamine derivative drug which acts as a 5-HT2B receptor agonist. It has anxiolytic effects in animal studies, and is also used for investigating the function of the 5-HT2B receptor in a range of other tissues.

Attributes	Values
rdf:type	Thing dul:ChemicalObject chemical substance Drug yago:Abstraction100002137 yago:Element114840755 yago:Matter100020827 yago:Part113809207 yago:PhysicalEntity100001930 yago:Quintessence114847103 yago:Relation100031921 drug yago:Substance100019613 yago:WikicatPhenolEthers umbel-rc:DrugProduct
rdfs:label	BW-723C86 (en) BW-723C86 (zh)
rdfs:comment	BW-723C86 is a tryptamine derivative drug which acts as a 5-HT2B receptor agonist. It has anxiolytic effects in animal studies, and is also used for investigating the function of the 5-HT2B receptor in a range of other tissues. (en)
foaf:depiction
dcterms:subject	Serotonin receptor agonists Tryptamines Indole ethers at the benzene ring 5-HT2B agonists Thiophenes
Wikipage page ID	20567407 (xsd:integer)
Wikipage revision ID	1104912788 (xsd:integer)
Link from a Wikipage to another Wikipage	In vitro Serotonin receptor agonists Tryptamines Anxiolytic Skin whitening Microphthalmia-associated transcription factor Tryptamine 5-Benzyloxytryptamine 6-APB Agonist dbr:5-HT2B_receptor Indole ethers at the benzene ring Receptor (biochemistry) 5-HT2B agonists Thiophenes Tyrosinase Enzyme inhibition Genetic expression Tyrosinase-related protein 1 Tyrosinase-related protein 2
sameAs	BW-723C86 BW-723C86 BW-723C86 BW-723C86 BW-723C86 BW-723C86 BW-723C86
dbp:wikiPageUsesTemplate	dbt:Drugbox dbt:R dbt:Reflist dbt:Refn dbt:Serotonergics dbt:Short_description dbt:Tryptamines dbt:Cascite dbt:Chemspidercite dbt:Fdacite dbt:Stdinchicite dbt:Anxiolytic-stub
thumbnail	wiki-commons:Special:FilePath/BW-723C86.svg?width=300
c	16 (xsd:integer)
CAS number	160521 (xsd:integer)
ChemSpiderID	3491208 (xsd:integer)
H	18 (xsd:integer)
IUPAC name	1 (xsd:integer)
n	2 (xsd:integer)
O	1 (xsd:integer)
PubChem	4284720 (xsd:integer)
s	1 (xsd:integer)
SMILES	c2c1cccc2OCc3cccs3 (en)
StdInChI	1 (xsd:integer)
StdInChIKey	ALFGDCNSEBJYSP-UHFFFAOYSA-N (en)
UNII	8 (xsd:integer)
Verifiedfields	changed (en)
verifiedrevid	449578639 (xsd:integer)
Watchedfields	changed (en)
width	220 (xsd:integer)
has abstract	BW-723C86 is a tryptamine derivative drug which acts as a 5-HT2B receptor agonist. It has anxiolytic effects in animal studies, and is also used for investigating the function of the 5-HT2B receptor in a range of other tissues. BW-723C86 is actually a mixed 5-HT2B/5-HT2C agonist, and while it has good selectivity over 5-HT2A and other serotonin receptor subtypes, it is around only 3 times as selective for 2B compared to 2C and so is much less selective than most research ligands, but no superior 5-HT2B agonist was available until the potent and selective 5-HT2B activity of 6-APB was discovered in 2012. Highly selective 5-HT2C antagonists are available however, and so a combination of BW-723C86 with a selective 5-HT2C antagonist allows 5-HT2B mediated responses to be studied in isolation. An in vitro study including assay on normal (healthy) human melanocytes found that BW-723C86 causes skin whitening. The mechanism of action of BW-723C86 is decreasing the expression of MITF which in turn, decreases the expression of the melanin main synthesizing enzymes: tyrosinase, TRP-1 and TRP-2. BW-723C86 is not cytotoxic to melanocytes and, unlike many skin whitening agents, does not directly inhibit the activity of tyrosinase. (en)
IUPHAR ligand	161 (xsd:integer)
gold:hypernym	Drug
prov:wasDerivedFrom	wikipedia-en:BW-723C86?oldid=1104912788&ns=0
page length (characters) of wiki page	6747 (xsd:nonNegativeInteger)
CAS number	160521-72-2
FDA UNII code	8JMH6M2ELN
PubChem	4284720
foaf:isPrimaryTopicOf	wikipedia-en:BW-723C86
is Link from a Wikipage to another Wikipage of	BW723C86 C16H18N2OS 5-Benzyloxytryptamine 6-APB dbr:5-HT2B_receptor 5-HT receptor Substituted tryptamine
is Wikipage redirect of	BW723C86

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