About: Belantamab mafodotin     Goto   Sponge   NotDistinct   Permalink

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Belantamab mafodotin, sold under the brand name Blenrep, is a medication for the treatment of relapsed and refractory multiple myeloma. The most common adverse reactions include keratopathy (corneal epithelium change on eye exam), decreased visual acuity, nausea, blurred vision, pyrexia, infusion-related reactions, and fatigue. Belantamab mafodotin was approved for medical use in the United States and in the European Union in August 2020. The U.S. Food and Drug Administration (FDA) considers it to be a first-in-class medication.

AttributesValues
rdf:type
rdfs:label
  • Belantamab mafodotin (en)
  • Белантамаб мафодотин (ru)
rdfs:comment
  • Белантамаб мафодотин — конъюгат антитело-препарат для лечения множественной миеломы. Одобрен для применения: ЕС, США (2020). (ru)
  • Belantamab mafodotin, sold under the brand name Blenrep, is a medication for the treatment of relapsed and refractory multiple myeloma. The most common adverse reactions include keratopathy (corneal epithelium change on eye exam), decreased visual acuity, nausea, blurred vision, pyrexia, infusion-related reactions, and fatigue. Belantamab mafodotin was approved for medical use in the United States and in the European Union in August 2020. The U.S. Food and Drug Administration (FDA) considers it to be a first-in-class medication. (en)
foaf:depiction
  • http://commons.wikimedia.org/wiki/Special:FilePath/Mafodotin_ADCs.svg
dcterms:subject
Wikipage page ID
Wikipage revision ID
Link from a Wikipage to another Wikipage
Link from a Wikipage to an external page
sameAs
dbp:wikiPageUsesTemplate
thumbnail
ATC suffix
  • FX15 (en)
ATC prefix
  • L01 (en)
CAS number
class
DrugBank
  • DB15719 (en)
KEGG
  • D11595 (en)
legal US
  • Rx-only (en)
routes of administration
source
  • zu (en)
synonyms
  • belantamab mafodotin-blmf, GSK2857916 (en)
target
tradename
  • Blenrep (en)
type
  • mab (en)
UNII
  • DB1041CXDG (en)
has abstract
  • Belantamab mafodotin, sold under the brand name Blenrep, is a medication for the treatment of relapsed and refractory multiple myeloma. The most common adverse reactions include keratopathy (corneal epithelium change on eye exam), decreased visual acuity, nausea, blurred vision, pyrexia, infusion-related reactions, and fatigue. Belantamab mafodotin is a humanized IgG1κ monoclonal antibody against the B-cell maturation antigen (BCMA) conjugated with a cytotoxic agent, maleimidocaproyl monomethyl auristatin F (mcMMAF). The antibody-drug conjugate binds to BCMA on myeloma cell surfaces causing cell cycle arrest and inducing antibody-dependent cellular cytotoxicity. Belantamab mafodotin was approved for medical use in the United States and in the European Union in August 2020. The U.S. Food and Drug Administration (FDA) considers it to be a first-in-class medication. On November 22, 2022, GSK plc announced it initiated the process for withdrawal of the United States marketing authorization for belantamab mafodotin following the request of the U.S. FDA. This request was based on the outcome of the DREAMM-3 phase III confirmatory trial, which did not meet the requirements of the U.S. FDA Accelerated Approval regulations. (en)
  • Белантамаб мафодотин — конъюгат антитело-препарат для лечения множественной миеломы. Одобрен для применения: ЕС, США (2020). (ru)
Chemical Formula
  • C6484H10008N1728O2030S44. 4 (en)
DailyMedID
  • Belantamab_mafodotin (en)
legal EU
  • Rx-only (en)
mab type
  • mab (en)
chemical formula
  • C6484H10008N1728O2030S44. (C49H66N6O11)4
prov:wasDerivedFrom
page length (characters) of wiki page
alternative name
  • Blenrep (en)
CAS number
  • 2050232-20-5
DrugBank
  • DB15719
FDA UNII code
  • DB1041CXDG
KEGG
  • D11595
class
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