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Benactyzine is an anticholinergic drug that was used as an antidepressant in the treatment of depression and associated anxiety before it was pulled from the U.S. market by the FDA due to its ineffectiveness. Its use for these indications was limited by side effects such as dry mouth and nausea, and at high doses it can cause more severe symptoms such as deliriant and hallucinogenic effects. "Large doses of benactyzine in normal subjects may produce a state resembling the action of mescaline or LSD."

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  • بيناكتيزين (ar)
  • Benactyzine (en)
  • Benactizina (it)
  • Bénactyzine (fr)
  • Бенактизин (ru)
rdfs:comment
  • بيناكتيزين (بالإنجليزية: Benactyzine)‏ هو دواء يُستعمل في علاج: * اضطراب القلق (ar)
  • La bénactyzine est un médicament anticholinergique qui a été utilisé comme antidépresseur dans le traitement de la dépression et associé à des formes d'anxiété avant d'être retiré du marché américain par la FDA en raison de son inefficacité. Son utilisation était limitée par ses effets secondaires tels que la xérostomie (sécheresse de la bouche) et les nausées et, à plus haute dose, des symptômes plus sévères tels que des effets hallucinogènes. Bien qu'il y ait des indices d'efficacité lorsqu'il est associé au méprobamate, son utilisation clinique n'est plus significative. (fr)
  • La benactizina, usata come cloridrato, è un farmaco dotato di attività antidepressiva e antimuscarinica. La molecola fu sintetizzata nel 1936 dai Ciba Laboratories. In passato è stata usata per il trattamento di disordini psiconeurotici e dei disturbi d'ansia. (it)
  • Бенактизин (Амизил, Amizylum) — антихолинергический препарат, используемый в качестве транквилизатор при лечении депрессии и тревоги. 2-Диэтиламиноэтилового эфира бензиловой кислоты гидрохлорид.Синонимы: Бенактизин, Actozine, Amitakon, Benactina, Benactyzine, Benactyzinum, Cafron, Cevanol, Lucidil, Nervatil, Neurobenzile, Parasan, Phobex, Procalm, Suavitil, Tranquilline и др. По химическому строению и фармакологическим свойствам близок к сложным эфирам дифенилуксусной кислоты (спазмолитин и др.), близким по структуре и эффектам является препарат Этпенал. (ru)
  • Benactyzine is an anticholinergic drug that was used as an antidepressant in the treatment of depression and associated anxiety before it was pulled from the U.S. market by the FDA due to its ineffectiveness. Its use for these indications was limited by side effects such as dry mouth and nausea, and at high doses it can cause more severe symptoms such as deliriant and hallucinogenic effects. "Large doses of benactyzine in normal subjects may produce a state resembling the action of mescaline or LSD." (en)
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  • none (en)
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  • DB09023 (en)
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  • D07498 (en)
legal status
  • Rx-only (en)
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  • Oral (en)
SMILES
  • O=CCc2ccccc2 (en)
StdInChI
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