Lieutenant Colonel Besby Frank Holmes (December 5, 1917 – July 23, 2006) was a American fighter pilot who in April 1943 took part in Operation Vengeance, a notable American wartime effort to kill Japanese admiral Isoroku Yamamoto, who had planned the attack on Pearl Harbor. Holmes was awarded a Navy Cross for his role in the mission, and later earned the Distinguished Flying Cross (with two oak leaf clusters) and an Air Medal.