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About: Beta-globin co-transcriptional cleavage ribozyme     Goto   Sponge   NotDistinct   Permalink

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The Beta-globin co-transcriptional cleavage ribozyme (CotC ribozyme) was proposed to be an RNA enzyme known as a ribozyme. Transcription termination of RNA polymerase II transcripts is proposed to occur by a two-stage process. The first stage involves pre-termination cleavage (PTC) of the nascent transcript downstream of the poly(A) site. This process is also referred to as co-transcriptional cleavage (CoTC). The CoTC process in the human beta-globin gene was proposed to involve an RNA self-cleaving activity located in the 3' flanking region of the beta-globin gene. The CoTC core is highly conserved in the 3' UTR of other primate beta-globin genes.