The Bruhrain Railway (German: Bruhrainbahn) is a railway line running from Bruchsal to Germersheim in the German states of Baden-Württemberg and Rhineland-Palatinate. Whilst it was part of a national trunk line (Magistrale) and handled long-distance traffic; today the line is exclusively worked by local trains. It takes its name from the , a region in the northwestern part of Karlsruhe district, which it passes through.