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About: dbr:Carbenoxolone     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : umbel-rc:DrugProduct, within Data Space : dbpedia.demo.openlinksw.com associated with source document(s)

Type: Thingdul:ChemicalObjectchemical substanceDrugyago:WikicatCarboxylateEstersyago:WikicatMolecularFormulasyago:WikicatSteroidsyago:Abstraction100002137yago:Acid114607521yago:Chemical114806838yago:Communication100033020yago:Compound114818238yago:Ester114850483yago:Formula106816935yago:Ketone114926294yago:Material114580897yago:Matter100020827yago:Message106598915yago:MolecularFormula106817173yago:OrganicCompound114727670yago:Part113809207yago:PhysicalEntity100001930yago:Relation100031921yago:WikicatKetoneschemical compounddrugyago:Statement106722453yago:Steroid115057744yago:Substance100019613yago:WikicatDicarboxylicAcidsumbel-rc:DrugProduct New Facet based on Instances of this Class

Carbenoxolone (CBX) is a glycyrrhetinic acid derivative with a steroid-like structure, similar to substances found in the root of the licorice plant. Carbenoxolone is used for the treatment of peptic, esophageal and oral ulceration and inflammation. Electrolyte imbalance is a serious side effect of carbenoxolone when used systemically. Carbenoxolone reversibly inhibits the conversion of inactive cortisone to cortisol by blocking 11β-hydroxysteroid dehydrogenase (11β-HSD). 11β-HSD also reversibly catalyzes the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol.