Charles Knight MD FRCP OBE is a British professor of cardiology and chief executive of St Bartholomew's Hospital, part of Barts Health NHS Trust. In 1994 he assisted in the first percutaneous alcohol septal ablation, a non-surgical method for the treatment of hypertrophic obstructive cardiomyopathy as an alternative to open heart surgery, and subsequently specialised in the procedure. From 2010 he led the development of the Barts Heart Centre at Barts Health NHS Trust which opened in 2015 by merging cardiac services from the London Chest Hospital, The Heart Hospital and St Bartholomew's Hospital.