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About: Clevegen     Goto   Sponge   NotDistinct   Permalink

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Clevegen (Bexmarilimab) is a new cancer immunotherapy drug under development in Finland by Faron Pharmaceuticals. The drug is an anti-Clever-1 antibody which can convert immune suppressive type-2 tumour-associated macrophages (TAMs) to immune active type-1 microphages and has the potential for wide use in oncology. It is currently (2019) undergoing trials (codename MATINS) as an innovative treatment for metastatic or inoperable solid tumours such as cutaneous melanoma and hepatobiliary/hepatocellular, pancreatic, ovarian and colorectal cancers, all of which host a significant number of Clever-1-positive TAMs and represent some 2 million cases annually worldwide.