State Highway 141 (SH 141) is a 162.297 mi (261.192 km) long state highway in far western Colorado, United States. Though nominally oriented north–south, SH 141 winds around a considerable amount due to the rugged terrain and ultimately forms a giant S shape. SH 141's southern terminus is at U.S. Route 491 (US 491) near Dove Creek, and the northern terminus is at Interstate 70 Business (I-70 Bus.) in Grand Junction. SH 141 is the longest three-digit state highway in Colorado.