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About: Cucurmosin     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : yago:Whole100003553, within Data Space : dbpedia.demo.openlinksw.com associated with source document(s)

Type: yago:WikicatWorksAboutCanceryago:Artifact100021939yago:Creation103129123yago:EndProduct103287178yago:Object100002684yago:Oeuvre103841417yago:PhysicalEntity100001930yago:Product104007894yago:Whole100003553 New Facet based on Instances of this Class

Cucurmosin is a type I ribosome inactivating protein (RIP) found in the sarcocarp (flesh) and seed of Cucurbita — notably Cucurbita moschata, that is toxic to cancer cells, if the dosage is high enough, by stopping their ribosomes. Cucurmosin is what Cucurbita use to defend against viral, fungal, and bacterial agents. It takes a lower dose of cucurmosin to kill cancer cells than healthy cells. It has been shown to induce apoptosis in pancreatic cancer and myeloid leukemia cells.