About: Cytomegalovirus vaccine

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A Cytomegalovirus vaccine is a vaccine to prevent cytomegalovirus (CMV) infection or curb virus re-activation (symptomatic flare-ups) in persons already infected. Challenges in developing a vaccine include adeptness of CMV in evading the immune system and limited animal models. As of 2018 no such vaccine exists, although a number of vaccine candidates are under investigation. They include recombinant protein, live attenuated, DNA and other vaccines. Development of such a vaccine has been emphasized as a priority by the National Vaccine Program Office in the United States.

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rdf:type	yago:WikicatVaccines yago:Antigen115037339 yago:Immunogen103562739 yago:Matter100020827 yago:PhysicalEntity100001930 drug yago:Substance100020090 yago:Vaccine104517535
rdfs:label	Cytomegalievirusimpfstoff (de) Cytomegalovirus vaccine (en)
rdfs:comment	Ein Cytomegalievirusimpfstoff (synonym CMV-Impfstoff) ist ein Impfstoff gegen das Cytomegalievirus (CMV). Es gibt bisher (2021) keine zugelassenen Cytomegalievirusimpfstoffe. (de) A Cytomegalovirus vaccine is a vaccine to prevent cytomegalovirus (CMV) infection or curb virus re-activation (symptomatic flare-ups) in persons already infected. Challenges in developing a vaccine include adeptness of CMV in evading the immune system and limited animal models. As of 2018 no such vaccine exists, although a number of vaccine candidates are under investigation. They include recombinant protein, live attenuated, DNA and other vaccines. Development of such a vaccine has been emphasized as a priority by the National Vaccine Program Office in the United States. (en)
dcterms:subject	Vaccines
Wikipage page ID	21116237 (xsd:integer)
Wikipage revision ID	1075736258 (xsd:integer)
Link from a Wikipage to another Wikipage	Mortality rate DNA Vaccine Moderna Morbidity Phase 2 study Hematopoietic stem cell Viremia Atherosclerosis Astellas Pharma Vaccines Kidney transplantation TORCH complex City of Hope National Medical Center Human cytomegalovirus Organ transplantation National Vaccine Program Office VBI Vaccines dbr:GB_protein
sameAs	Cytomegalovirus vaccine Cytomegalovirus vaccine Cytomegalovirus vaccine Cytomegalovirus vaccine Cytomegalovirus vaccine
dbp:wikiPageUsesTemplate	dbt:Reflist dbt:Vaccines
has abstract	Ein Cytomegalievirusimpfstoff (synonym CMV-Impfstoff) ist ein Impfstoff gegen das Cytomegalievirus (CMV). Es gibt bisher (2021) keine zugelassenen Cytomegalievirusimpfstoffe. (de) A Cytomegalovirus vaccine is a vaccine to prevent cytomegalovirus (CMV) infection or curb virus re-activation (symptomatic flare-ups) in persons already infected. Challenges in developing a vaccine include adeptness of CMV in evading the immune system and limited animal models. As of 2018 no such vaccine exists, although a number of vaccine candidates are under investigation. They include recombinant protein, live attenuated, DNA and other vaccines. As a member of the TORCH complex, cytomegalovirus can cause congenital infection, which can lead to neurological problems, vision and hearing loss. Infection/re-activation of CMV in immuno-compromised persons, including organ transplantation recipients, causes significant mortality and morbidity. Additionally, CMV has strong associations with plaques found in atherosclerosis progression. Because of all these, there has been considerable effort made towards the development of a vaccine, with particular emphasis on protection of pregnant women. Since vaccination of the immunocompromised persons introduces additional challenges, members of this population are less likely to be candidates for such a vaccine. Additionally, there are additional health risks for individuals who are already not infected with CMV. For instance, CMV infection is strongly associated with development of Alzheimer's disease. Development of such a vaccine has been emphasized as a priority by the National Vaccine Program Office in the United States. (en)
gold:hypernym	Vaccine
prov:wasDerivedFrom	wikipedia-en:Cytomegalovirus_vaccine?oldid=1075736258&ns=0
page length (characters) of wiki page	8572 (xsd:nonNegativeInteger)
foaf:isPrimaryTopicOf	wikipedia-en:Cytomegalovirus_vaccine
is Link from a Wikipage to another Wikipage of	List of infectious diseases Timeline of human vaccines Moderna Cytomegalovirus vaccines List of vaccine topics CMV vaccine
is Wikipage redirect of	Cytomegalovirus vaccines CMV vaccine
is foaf:primaryTopic of	wikipedia-en:Cytomegalovirus_vaccine

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