De La Salle College is an independent Roman Catholic comprehensive single-sex secondary day school for boys, located in Ashfield, an inner-western suburb of Sydney, New South Wales, Australia. Established in 1916 by the De La Salle Brothers and Vincentian Fathers, the college caters to students in Year 7 to Year 12 from the inner-west Parishes of the Archdiocese of Sydney. The college is under the patronage of the Archbishop of Sydney, Anthony Fisher. De La Salle College is one of 18 Lasallian Schools in Australia, and in the 1970s became the first Catholic high school in Australia to have a lay headmaster.