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About: Discovery and development of gastrointestinal lipase inhibitors     Goto   Sponge   NotDistinct   Permalink

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Type: Thingdul:ChemicalObjectchemical substanceDrugdrug New Facet based on Instances of this Class

Lipase inhibitors belong to a drug class that is used as an antiobesity agent. Their mode of action is to inhibit gastric and pancreatic lipases, enzymes that play an important role in the digestion of dietary fat. Lipase inhibitors are classified in the ATC-classification system as A08AB (peripherally acting antiobesity products).Numerous compounds have been either isolated from nature, semi-synthesized, or fully synthesized and then screened for their lipase inhibitory activity but the only lipase inhibitor on the market (October 2016) is orlistat (Xenical, Alli).Lipase inhibitors have also shown anticancer activity, by inhibiting fatty acid synthase.