Donald Silvio Nesti, C.S.Sp. (born 1936) is an American Catholic priest in the Congregation of the Holy Spirit. He served as the tenth president of Duquesne University in Pittsburgh, Pennsylvania, from 1980 until 1988. He is the founder and current director of the Center for Faith and Culture at the University of Saint Thomas in Houston, Texas, and a professor of theology at St. Mary's Seminary, also in Houston.