About: EA-3443

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EA-3443 is a potent and long lasting anticholinergic deliriant drug, related to the chemical warfare agent 3-Quinuclidinyl benzilate (QNB). It was developed under contract to Edgewood Arsenal during the 1960s as part of the US military chemical weapons program, during research to improve upon the properties of earlier agents such as QNB.

Attributes	Values
rdf:type	Thing dul:ChemicalObject chemical substance Drug yago:WikicatAnticholinergics yago:Agent109190918 yago:Agent114778436 yago:Anticholinergic102717901 yago:CausalAgent100007347 yago:Drug103247620 yago:Matter100020827 yago:Medicine103740161 yago:PhysicalEntity100001930 yago:WikicatIncapacitatingAgents drug yago:Substance100020090 umbel-rc:DrugProduct
rdfs:label	EA-3443 (en)
rdfs:comment	EA-3443 is a potent and long lasting anticholinergic deliriant drug, related to the chemical warfare agent 3-Quinuclidinyl benzilate (QNB). It was developed under contract to Edgewood Arsenal during the 1960s as part of the US military chemical weapons program, during research to improve upon the properties of earlier agents such as QNB. (en)
foaf:depiction
dct:subject	Piperidines Deliriants Incapacitating agents Muscarinic antagonists Phenylcyclopentylglycolate esters
Wikipage page ID	23249993 (xsd:integer)
Wikipage revision ID	1085655416 (xsd:integer)
Link from a Wikipage to another Wikipage	United States and weapons of mass destruction Piperidines Anticholinergic Deliriant 3-Quinuclidinyl benzilate Deliriants Incapacitating agents Muscarinic antagonists EA-3167 Ditran Phenylcyclopentylglycolate esters Edgewood Arsenal experiments Chemical weapons N-ethyl-3-piperidyl benzilate N-methyl-3-piperidyl benzilate
sameAs	EA-3443 EA-3443 EA-3443 EA-3443 EA-3443 EA-3443
dbp:wikiPageUsesTemplate	dbt:Chemical_agents dbt:Drugbox dbt:Hallucinogens dbt:Reflist dbt:Short_description dbt:Drugbankcite dbt:Fdacite dbt:Muscarinic_acetylcholine_receptor_modulators dbt:Hallucinogen-stub
thumbnail	wiki-commons:Special:FilePath/EA-3443_structure.png?width=300
c	19 (xsd:integer)
CAS number	37830 (xsd:integer)
ChemSpiderID	34695 (xsd:integer)
H	27 (xsd:integer)
IUPAC name	2 (xsd:integer)
n	1 (xsd:integer)
O	3 (xsd:integer)
PubChem	37838 (xsd:integer)
SMILES	C1CNCCC1OCCc2ccccc2 (en)
StdInChI	1 (xsd:integer)
StdInChIKey	DZFJGXMHIMAYMW-UHFFFAOYSA-N (en)
UNII	90 (xsd:integer)
verifiedrevid	424815733 (xsd:integer)
Watchedfields	changed (en)
width	240 (xsd:integer)
has abstract	EA-3443 is a potent and long lasting anticholinergic deliriant drug, related to the chemical warfare agent 3-Quinuclidinyl benzilate (QNB). It was developed under contract to Edgewood Arsenal during the 1960s as part of the US military chemical weapons program, during research to improve upon the properties of earlier agents such as QNB. The main advantages of EA-3443 were not only increased potency over QNB, but also a significantly improved central to peripheral effects ratio. Anticholinergic drugs produce both incapacitating deliriant effects through action in the brain, and a variety of distinctive physical symptoms such as dry mouth, dilated pupils, blurred vision and hot flushed skin, all of which together comprise the "anticholinergic syndrome" which is generally easy for doctors to diagnose. EA-3443 however is mainly selective for the brain, and when administered in a narrow dose range of around 0.3 mg can produce the central effects of confusion, hallucinations and amnesia, but without producing significant physical symptoms, which was predicted to make poisoning with EA-3443 much more difficult to diagnose and treat. However, despite these advantages, EA-3443 was never researched to the same extent as QNB or manufactured in bulk, and research into EA-3443 was discontinued along with the rest of the US chemical weapons program in the mid-1970s. (en)
gold:hypernym	Drug
prov:wasDerivedFrom	wikipedia-en:EA-3443?oldid=1085655416&ns=0
page length (characters) of wiki page	3999 (xsd:nonNegativeInteger)
CAS number	37830-21-0
FDA UNII code	90H2V46IP4
PubChem	37838
foaf:isPrimaryTopicOf	wikipedia-en:EA-3443
is Link from a Wikipage to another Wikipage of	CAR-226,086 CB military symbol 3-Quinuclidinyl benzilate EA-3580 EA-3834 Edgewood Arsenal human experiments C19H27NO3 CAR-301,060
is foaf:primaryTopic of	wikipedia-en:EA-3443

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