Edward Dwight Holton (April 28, 1815 – April 21, 1892) was a nineteenth century Wisconsin political and business leader. Holton was Milwaukee's first sheriff and was a member of the Wisconsin State Assembly, but despite never holding a higher office he was influential in the early political development of the state. He was a candidate in the pivotal 1857 gubernatorial campaign, and was well known as an important leader on the subjects of abolitionism and temperance. He also had a strong influence on the development of the state through his involvement in the banking, railroad and insurance businesses.