Ependymin is a glycoprotein found in the cerebrospinal fluid of many teleost fish. The humans homolog is called ependymin related 1 that is encoded by the EPDR1 gene. Ependymin is associated with the consolidation of long-term memory, possibly providing protection from strokes, and contributing to neuronal regeneration. This encoded protein was originally detected in elevated amounts of fluid within the central nervous system of teleost fishes. Along with long-term memory and neuronal regeneration, ependymin has been connected to specific aspects of changes in signaling within nerve cells leading to brain plasticity, as well as behavioral performance in response to environment stress in fishes. For example, this glycoprotein interaction in the extracellular matrix influences cell adhesion
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| - Ependymin (de)
- Ependymin (en)
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| - Ependymin ist ein Glykoprotein, das im Gehirn von Knochenfischen aus dem Ependym und aus der Extrazellularflüssigkeit isoliert wurde. Es handelt sich um ein Adhäsionsmolekül. Bei Amphibien, Säugetieren und beim Menschen wurden ähnliche Moleküle gefunden, die ependymin related proteins (ERP) genannt werden. (de)
- Ependymin is a glycoprotein found in the cerebrospinal fluid of many teleost fish. The humans homolog is called ependymin related 1 that is encoded by the EPDR1 gene. Ependymin is associated with the consolidation of long-term memory, possibly providing protection from strokes, and contributing to neuronal regeneration. This encoded protein was originally detected in elevated amounts of fluid within the central nervous system of teleost fishes. Along with long-term memory and neuronal regeneration, ependymin has been connected to specific aspects of changes in signaling within nerve cells leading to brain plasticity, as well as behavioral performance in response to environment stress in fishes. For example, this glycoprotein interaction in the extracellular matrix influences cell adhesion (en)
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| - Mammalian Ependymin-Related Protein 1, Upregulated In Colorectal Cancer Gene 1 Protein (en)
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| - Ependymin ist ein Glykoprotein, das im Gehirn von Knochenfischen aus dem Ependym und aus der Extrazellularflüssigkeit isoliert wurde. Es handelt sich um ein Adhäsionsmolekül. Bei Amphibien, Säugetieren und beim Menschen wurden ähnliche Moleküle gefunden, die ependymin related proteins (ERP) genannt werden. Ependymin tritt in zwei Glykosylierungsvarianten auf: eine 31 kDa schwere mono-N-glykosylierte Form und eine 37 kDa bi-N-glykosylierte Form. Im Liquor cerebrospinalis und der extrazellulären Matrix des Goldfisches kommt Ependymin mit 15 % Proteinanteil vor und kann als Mono-, Di- und Polymer nachgewiesen werden, wobei die Monomere durch Calciumionen und die Dimere durch Zinkionen stabilisiert werden. Obwohl Ependymine in den Fibroblasten der Meninx hergestellt werden, findet man sie auch an Neuronen wieder. Die biologischen Funktionen der Ependymine sind noch weitgehend unbekannt. Sie könnten an der Gedächtniskonsolidierung beteiligt sein, da gezeigt werden konnte, dass sie nach einer vestibulomotorischen Konditionierung von Goldfischen einen erhöhten Turnover aufwiesen. Ependymine scheinen weder beim Lernen, noch beim Kurzzeitgedächtnis, noch bei der Erinnerungsleistung der Goldfische involviert, nur bei der Konsolidierung des Langzeitgedächtnisses. (de)
- Ependymin is a glycoprotein found in the cerebrospinal fluid of many teleost fish. The humans homolog is called ependymin related 1 that is encoded by the EPDR1 gene. Ependymin is associated with the consolidation of long-term memory, possibly providing protection from strokes, and contributing to neuronal regeneration. This encoded protein was originally detected in elevated amounts of fluid within the central nervous system of teleost fishes. Along with long-term memory and neuronal regeneration, ependymin has been connected to specific aspects of changes in signaling within nerve cells leading to brain plasticity, as well as behavioral performance in response to environment stress in fishes. For example, this glycoprotein interaction in the extracellular matrix influences cell adhesion and migration processes in the central nervous system of teleost fishes. The presence of ependymin-related proteins can be found in both vertebrates and invertebrates. They have variety of functional roles in non-neural sites of organisms. For example, an ependymin-related gene that is upregulated in colon cancer known as UCC1 was found in human colorectal tumor cells. (en)
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