State Road 78 (SR 78) is the Florida Department of Transportation designation of the highway that historically extended from Pine Island Center on the Gulf Coast of Florida to the northern tip of Lake Okeechobee. In the 1980s, two segments of the route were removed from state maintenance to county maintenance (and the road designations were changed to reflect the action). More recently, SR 78 signs were removed from the four-mile-long stretch of US 27/SR 25 that was once a concurrency. All three sections are signed east–west, even though the easternmost section is actually a north–south route.