Frank Nesser (June 3, 1889 – January 1, 1953) was a professional football player in the "Ohio League" and the early National Football League. During his career he played mainly for the Columbus Panhandles, however he did also play for a little for the Akron Indians, whenever he was recruited by Indians manager, Peggy Parratt. Frank was a member of the Nesser Brothers, a group consisting of seven brothers who made-up the most famous football family in the United States from 1907 until the mid-1920s.