Gene Weltfish (born Regina Weltfish) (August 7, 1902 – August 2, 1980) was an American anthropologist and historian working at Columbia University from 1928 to 1953. She had studied with Franz Boas and was a specialist in the culture and history of the Pawnee people of the Midwest Plains. Her 1965 ethnography, The Lost Universe: Pawnee Life and Culture, is considered the authoritative work on Pawnee culture to this day.