State Route 72 (SR 72) is a 46.7-mile-long (75.2 km) state highway that runs west-to-east through portions of Clarke, Madison, and Elbert counties in the northeastern part of the U.S. state of Georgia. This route is part of a multi two-state route 72 that begins at Athens, Georgia and ends at Rock Hill, South Carolina. The route connects the Athens area with the South Carolina state line, southwest of Calhoun Falls, South Carolina, via Comer and Elberton.