German submarine U-216 was a Type VIID mine-laying U-boat of Nazi Germany's Kriegsmarine during World War II. Her keel was laid down 1 January 1941 by Germaniawerft in Kiel as yard number 648. She was launched on 23 October 1941 and commissioned on 15 December 1941 with Oberleutnant zur See Karl-Otto Schultz in command.