Gilbert Louis Dupré Sr. (September 20, 1858 – December 18, 1946), was a self-educated lawyer and state representative from Opelousas, Louisiana, known for his initial political opposition to Governor Huey Pierce Long Jr. He held his state House seat from 1913 to 1932. A native of St. Landry Parish in South Louisiana, he maintained his legal office for many years in Opelousas. In his last year in office, Dupré, by then an elderly deaf man, spoke out against the Long intra-party challenger, Dudley LeBlanc of Abbeville through the Long newspaper, the Louisiana Progress.