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About: HERG     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : yago:WikicatProteinComplexes, within Data Space : dbpedia.demo.openlinksw.com associated with source document(s)

Type: ThingBiomoleculegeneBiomoleculeGeneyago:Abstraction100002137yago:Act100030358yago:Channel106259898yago:Chemical114806838yago:Cognition100023271yago:Communication106252138yago:Complex105870365yago:Compound114818238yago:Concept105835747yago:Content105809192yago:Event100029378yago:Idea105833840yago:Macromolecule114944888yago:Material114580897yago:Matter100020827yago:Molecule114682133yago:OrganicCompound114727670yago:Part113809207yago:PhysicalEntity100001930yago:Protein114728724yago:PsychologicalFeature100023100yago:Relation100031921yago:WikicatHumanProteinsyago:WikicatIonChannelsyago:YagoPermanentlyLocatedEntityHumanGeneproteinyago:Substance100019613yago:Thing100002452yago:Transmission106251781yago:Unit109465459yago:Whole105869584yago:WikicatProteinComplexes New Facet based on Instances of this Class

hERG (the human Ether-à-go-go-Related Gene) is a gene (KCNH2) that codes for a protein known as Kv11.1, the alpha subunit of a potassium ion channel. This ion channel (sometimes simply denoted as 'hERG') is best known for its contribution to the electrical activity of the heart: the hERG channel mediates the repolarizing IKr current in the cardiac action potential, which helps coordinate the heart's beating. hERG has also been associated with modulating the functions of some cells of the nervous system and with establishing and maintaining cancer-like features in leukemic cells.