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About: Intracellular antibody-mediated degradation     Goto   Sponge   NotDistinct   Permalink

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Intracellular antibody-mediated degradation (IAMD) is a neutralization mechanism of intracellular antibody-mediated immunity whereby an effector protein, TRIM21, directs antibody bound virions to the proteasome where they are degraded. As yet, it has only been observed to act against the adenovirus but is likely to also be effective against other non-enveloped viruses.